Campus research facilities
The University of Missouri provides many effective and efficient research facilities that are available to biochemistry faculty, staff and students. The list below is a selection of those most relevant to biochemical research.
Confocal and related microscopy. The Molecular Cytology Core has up-to-date facilities for confocal and wide field light microscopy, laser-capture microdissection and image analysis.
DNA analysis. The DNA Core offers high throughput and routine DNA sequencing, genotyping and analysis of DNA fragments, genomic variation and gene expression.
Electron microscopy. The Electron Microscopy Core has multiple instruments for scanning and transmission electron microscopy, providing investigators with consultation, training, access to instrumentation and extensive services.
Hybridomas and flow cytometry. The Cell and Immunobiology Core provides services for tissue culture, hybridoma preparation and monoclonal antibody preparation. In addition, it has five state-of-the-art flow cytometry instruments.
Macromolecular X-Ray Diffraction. State-of-the-art X-ray diffraction equipment for the analysis of macromolecular crystals is housed in the Bond Life Sciences Center.
Molecular Interactions and Structural Biology. The Molecular Interactions Core provides equipment maintenance and infrastructure support for structural biology research and computation, dynamic light scattering, peptide synthesis and custom LC-MS. The core offers all of the services necessary to take crystallography, dynamic light scattering, NMR, or peptide synthesis projects from start to finish.
Nuclear magnetic resonance (NMR) spectroscopy. The NMR Core provides sophisticated NMR capabilities. Five multinuclear, Fourier-transform instruments are available, operating at 800 MHz, 600 MHz, 500 MHz, and 300 MHz. The 800 MHz spectrometer is housed in Schweitzer Hall and the others in the chemistry building, which is connected to the Biochemistry Complex.
Nuclear reactor. The university's Research Reactor is the highest powered, highest flux university research reactor in the U. S. The facility provides intense sources of neutron, gamma and neutrino radiation for research and applications.
Proteomics and mass spectrometry. The Charles W. Gehrke Proteomics Center has multiple state-of-the-art mass spectrometers plus expertise to perform all aspects of contemporary proteomic studies as well as mass spectrometry of individual proteins. Watch a video tour of the facility led by Brian Mooney, a biochemistry assistant research professor and associate director of the center.
Structural biology. The Structural Biology Core provides equipment maintenance and infrastructure support for structural biology research and structural biology computation. In addition it manages a peptide synthesis service.
Synchrotron beamline. MU is a member of the Molecular Biology Consortium that built and operates Beamline 4.2.2 of the Advanced Light Source at Lawrence Berkeley National Laboratory. 4.2.2 is a state-of-the-art tunable superbend beamline for high-resolution diffraction studies of macromolecular crystals.
Transgenic mice. The Transgenic Animal Core can create transgenic mice by pronuclear injection and stem cell targeting.