Susan L. Deutscher
Professor of Biochemistry
E-mail:deutschers@missouri.edu
Office: 234C Schweitzer Hall
Mail: Biochemistry
117 Schweitzer Hall
University of Missouri
Columbia, MO 65211
Phone: 573-882-2454
Fax: 573-882-5635
Lab: 573-882-1493
Educational background
| Degree | School | Location | Major |
| BS | Purdue University | West Lafayette, Ind. | Cell Biology |
| PhD | St. Louis University | St. Louis, Mo. | Biochemistry |
Notable honors and service
- Co-director, NIH/NEI Center for Single Photon-Emitting Cancer-Imaging Agents
- Veterans Administration Research Merit Award (1994-96; 1998-2010)
Research description
Our laboratory is interested in discerning the role of carbohydrate and protein-protein interactions in cancer. Work focuses on applying novel combinatorial phage display approaches and structural biochemistry to characterize these interactions. Combinatorial chemistry and phage display allows for the rapid selection from many millions of sequences to find peptide molecules that bind almost any given target such as cancer antigens. We have isolated peptides that are being utilized to specifically modulate cancer cell adhesion events. Once radiolabeled, the peptides will prove valuable as selective cancer imaging and therapeutic agents.
Selected publications
Landon, L., Zou, J., and Deutscher, S.L. (2004) Is Phage Display Technology on Target for Developing Peptide-based Drugs? Current Drug Discovery Technologies, 1, 113-132.
Newton JR, Kelly KA, Mahmood U, Weissleder R and Deutscher SL. (2006) In vivo selection of phage for the optical imaging of human prostate carcinoma in mice. Neoplasia 8, 772-780
Newton, JR, Miao, Y, Deutscher, SL and Quinn, TP. (2007) Melanoma Imaging with Pretargeted Bivalent Bacteriophage. Journal of Nuclear Medicine 48, 429-436.
Kumar S.R., Quinn T.P., Deutscher S.L. (2007) Evaluation of an 111In-radiolabeled peptide as a targeting and imaging agent for ErbB-2 receptor expressing breast carcinomas. Clin. Cancer Res. 13 (20): 6070-9
Kumar, S. and Deutscher, S.L. (2008) 111In-Labeled Galectin-3-targeting Peptide as a SPECT Breast Tumor Imaging Agent. Journal of Nuclear Medicine 49, 796-803
Newton J., Deutscher S.L. (2008) Phage peptide display. Handb. Exp. Pharmacol. 185 Pt 2: 145-63
Deutscher S.L., Figueroa S.D., Kumar S.R. (2009) Tumor targeting and SPECT imaging properties of an (111)In-labeled galectin-3 binding peptide in prostate carcinoma. Nucl. Med. Biol. 36 (2): 137-46
Newton-Northup, J.R., Figueroa, S.D., Quinn, T.P., and Deutscher, S.L. (2009) Bifunctional Phage-Based Pretargeted Imaging of Human Prostate Carcinoma, Nucl. Med. Biol., 36: 789
Employment opportunities
Postdoctoral opportunities
Research areas: Combinatorial biology applied to cancer detection and therapy.
How to apply:
Electronic submission is encouraged, e-mail to deutschers@missouri.edu
Applicants should send CV and names of two references to:
Dr. Susan L. Deutscher
Biochemistry
117 Schweitzer Hall
University of Missouri
Columbia, MO 65211