Office: 127 Schweitzer Hall
117 Schweitzer Hall
University of Missouri
Columbia, MO 65211
|BS||Korea University||Seoul, Korea||Biology|
|MS||Korea University||Seoul, Korea||Molecular Biology and Genetics|
|PhD||Michigan State University||East Lansing, Mich.||Plant Biology|
Our lab’s research involves the study of small signaling molecules that cells use to detect extracellular stimuli and to coordinate intra- and intercellular responses. To compensate for their lack of mobility, plant cells rely heavily on chemical cues to interact with their surroundings—one reason why plants are so rich in pharmaceuticals and provide attractive models for studying chemically mediated cell signaling. We use highly sensitive and selective mass-spectrometry-based methodologies to capture and to monitor plants’ chemical messengers, which often exist in trace amounts. Using powerful analytical tools combined with the rich genetic and genomic resources available for the model plant Arabidopsis has allowed us to identify new players in defense signaling cascades within a plant’s immune response against insects and fungal pathogens. Recently, our focus has been to describe mechanisms that control optimal levels of plant hormone jasmonates (JAs). JAs are a group of oxylipins produced by the oxidative metabolism of polyunsaturated fatty acids, analogous to eicosanoids in animals. Similar to eicosanoids, JAs play an important role in mechanical stress-induced responses and plant immunity. Thus, knowledge obtained from this research has implications for use in applied agronomy as well as for the advancement of foundational science in the area of cross-kingdom, conserved chemical cell signaling. In addition, because JAs have been reported to have anti-cancerous effects on certain tumor cells and are master regulators of secondary metabolites in plants, many of which are antioxidants beneficial to humans, the study of JAs will contribute to overall human health.
Zhang T, Poudel AN, Jewell JB, Kitaoka N, Staswick P, Matsuura H, Koo AJ (2015) Hormone crosstalk in wound stress response: wound-inducible amidohydrolases can simultaneously regulate jasmonate and auxin homeostasis in Arabidopsis thaliana. J Exp Bot. pii: erv521. [Epub ahead of print]
Schneider A, Aghamirzaie D, Elmarakeby H, Poudel A, Koo AJ, Heath L, Grene R, Collakova E. (2015) Potential targets of VIVIPAROUS1/ABI3-LIKE1 (VAL1) repression in developing Arabidopsis thaliana embryos. Plant J. doi: 10.1111/tpj.13106. [Epub ahead of print]
Nguyen PD, Pike S, Wang J, Poudel AN, Heinz R, Schultz JC, Koo AJ, Mitchum MG, Appel HM, Gassmann W. (2015) The Arabidopsis immune regulator SRFR1 dampens defenses against herbivory by Spodoptera exigua and parasitism by Heterodera schachtii. Mol Plant Pathol. [Epub ahead of print]
Smith JM, Leslie ME, Robinson SJ, Korasick DA, Zhang T, Backues SK, Cornish PV, Koo AJ, Bednarek SY, Heese A. (2014) Loss of Arabidopsis thaliana Dynamin-Related Protein 2B Reveals Separation of Innate Immune Signaling Pathways. PLOS Pathogens 10:e1004578. eCollection.
Koo AJ, Thireault C, Zemelis S, Poudel AN, Zhang T, Kitaoka N, Brandizzi F, Matsuura H, Howe GA (2014) Endoplasmic Reticulum-Associated Inactivation of the Hormone Jasmonoyl-L-Isoleucine by Multiple Members of the Cytochrome P450 94 Family in Arabidopsis. J Biol Chem 289:29728-38.
Attaran E, Major IT, Cruz JA, Rosa BA, Koo AJ, Chen J, Kramer DM, He SY, Howe GA (2014) Temporal dynamics of Growth and Photosynthesis Suppression in Response to Jasmonate Signaling. Plant Physiol 165:1302-1314.
Bhosale R, Jewell JB, Hollunder J, Koo AJ, Vuylsteke M, Michoel T, Hilson P, Goossens A, Howe GA, Browse J, Maere S (2013) Predicting Gene Function from Uncontrolled Expression Variation among Individual Wild-Type Arabidopsis Plants. Plant Cell 25: 2865-2877.
Nakata M, Mitsuda N, Herde M, Koo AJ, Moreno JE, Howe GA, Suzuki K, Ohme-Takagi1 M (2013) A bHLH-Type Transcription Factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, Acts as a Repressor to Negatively Regulate Jasmonate Signaling in Arabidopsis. Plant Cell 25:1641-1656.
Herde M, Koo AJ, Howe GA (2013) Elicitation of jasmonate-mediated defense responses by mechanical wounding and insect herbivory. Methods Mol Biol 1011:51-61.
Sanjaya, Miller R, Durrett TP, Kosma DK, Lydic TA, Muthan B, Koo AJ, Bukhman YV, Reid GE, Howe GA, Ohlrogge J, Benning C (2013) Altered Lipid Composition and Enhanced Nutritional Value of Arabidopsis Leaves following Introduction of an Algal Diacylglycerol Acyltransferase 2. Plant Cell 25: 677-693.
Pourcel L, Irani NG, Koo AJ, Bohorquez-Restrepo A, Howe GA, Grotewold E (2013) A chemical complementation approach reveals genes and interactions of flavonoids with other pathways. Plant J. 74:383-397.
Koo AJ, Howe GA (2012) Catabolism and deactivation of the lipid-derived hormone jasmonoyl-isoleucine. Front. Plant Sci. 3:19.
Koo AJ, Cooke TF, Howe GA (2011) Cytochrome P450 CYP94B3 mediates catabolism and inactivation of the plant hormone jasmonoyl-L-isoleucine. Proc Natl Acad Sci U S A 108:9298-303.
Koo AJ, Howe GA (2009) The wound hormone jasmonates. Phytochemistry 70: 1571-1580.
Koo AJ, Gao X, Jones AD, Howe GA (2009) A rapid wound signal activates systemic synthesis of bioactive jasmonates in Arabidopsis. Plant J 59: 974-986.
A complete list of Koo’s publications can be found here.
Research areas: molecular biology, gene expression, hormone signaling, plant-insect interaction, plant metabolism
How to apply:
Electronic submission is encouraged, e-mail to firstname.lastname@example.org
Applicants should send CV and names of two references to:
Abraham JK Koo PhD
Department of Biochemistry &
Interdisciplinary Plant Group
University of Missouri
117 Schweitzer Hall
Columbia, MO, 65211