Office: 127 Schweitzer Hall
117 Schweitzer Hall
University of Missouri
Columbia, MO 65211
|BS||Korea University||Seoul, Korea||Biology|
|MS||Korea University||Seoul, Korea||Molecular Biology and Genetics|
|PhD||Michigan State University||East Lansing, Mich.||Plant Biology|
Our lab’s research involves the study of small signaling molecules that cells use to detect extracellular stimuli and to coordinate intra- and intercellular responses. To compensate for their lack of mobility, plant cells rely heavily on chemical cues to interact with their surroundings—one reason why plants are so rich in pharmaceuticals and provide attractive models for studying chemically mediated cell signaling. We use highly sensitive and selective mass-spectrometry-based methodologies to capture and to monitor plants’ chemical messengers, which often exist in trace amounts. Using powerful analytical tools combined with the rich genetic and genomic resources available for the model plant Arabidopsis has allowed us to identify new players in defense signaling cascades within a plant’s immune response against insects and fungal pathogens. Recently, our focus has been to describe mechanisms that control optimal levels of plant hormone jasmonates (JAs). JAs are a group of oxylipins produced by the oxidative metabolism of polyunsaturated fatty acids, analogous to eicosanoids in animals. Similar to eicosanoids, JAs play an important role in mechanical stress-induced responses and plant immunity. Thus, knowledge obtained from this research has implications for use in applied agronomy as well as for the advancement of foundational science in the area of cross-kingdom, conserved chemical cell signaling. In addition, because JAs have been reported to have anti-cancerous effects on certain tumor cells and are master regulators of secondary metabolites in plants, many of which are antioxidants beneficial to humans, the study of JAs will contribute to overall human health.
Nakata M, Mitsuda N, Herde M, Koo AJ, Moreno JE, Howe GA, Suzuki K, Ohme-Takagi1 M. A bHLH-Type Transcription Factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, Acts as a Repressor to Negatively Regulate Jasmonate Signaling in Arabidopsis. Plant Cell. (2013) May 14 [Epub ahead of print] PMID: 23673982
Herde M, Koo AJ, Howe GA. Elicitation of jasmonate-mediated defense responses by mechanical wounding and insect herbivory. Methods Mol Biol (2013) 1011:51-61.
Sanjaya, Miller R, Durrett TP, Kosma DK, Lydic TA, Muthan B, Koo AJ, Bukhman YV, Reid GE, Howe GA, Ohlrogge J, Benning C. Altered Lipid Composition and Enhanced Nutritional Value of Arabidopsis Leaves following Introduction of an Algal Diacylglycerol Acyltransferase 2. Plant Cell (2013) 25: 677-693.
Pourcel L, Irani NG, Koo AJ, Bohorquez-Restrepo A, Howe GA, Grotewold E A chemical complementation approach reveals genes and interactions of flavonoids with other pathways. Plant J. (2013) 74: 383-397.
Koo AJ, Howe GA. Catabolism and deactivation of the lipid-derived hormone jasmonoyl-isoleucine. Front. Plant Sci. (2012) 3:19.
Koo AJ, Cooke TF, Howe GA. Cytochrome P450 CYP94B3 mediates catabolism and inactivation of the plant hormone jasmonoyl-L-isoleucine. Proc Natl Acad Sci U S A. (2011) 108:9298-303.
Koo AJ, Howe GA. The wound hormone jasmonates. Phytochemistry. (2009) 70: 1571-1580.
Koo AJ, Gao X, Jones AD, Howe GA. A rapid wound signal activates systemic synthesis of bioactive jasmonates in Arabidopsis. Plant J. (2009) 59: 974-986.
Katsir L, Chung HS, Koo AJ, Howe GA. Jasmonate signaling: a conserved mechanism of hormone sensing. Curr Opin Plant Biol. (2008) 11: 428-435.
Chung HS, Koo AJ, Gao X, Jayanty S, Jones AD, Howe GA. Regulation and function of Arabidopsis JAZ genes in response to wounding and herbivory. Plant Physiol. (2008) 146: 952-964.
Li Y, Beisson F, Koo AJ, Molina I, Pollard M, Ohlrogge J. Identification of acyltransferases required for cutin biosynthesis and production of cutin with suberin-like monomers. Proc Natl Acad Sci U S A. (2007) 104: 18339-18344.
Koo AJ, Chung HS, Kobayashi Y, Howe GA. Identification of a peroxisomal acyl-activating enzyme involved in the biosynthesis of jasmonic acid in Arabidopsis. J Biol Chem. (2006) 281: 33511-33520.
Research areas: molecular biology, gene expression, hormone signaling, plant-insect interaction, plant metabolism
How to apply:
Electronic submission is encouraged, e-mail to email@example.com
Applicants should send CV and names of two references to:
Abraham JK Koo PhD
Department of Biochemistry &
Interdisciplinary Plant Group
University of Missouri
117 Schweitzer Hall
Columbia, MO, 65211