|BS||Nanjing Forestry University||Nanjing, China||Forest Products Chemistry|
|PhD||Virginia Tech||Blacksburg, Va.||Wood Chemistry and Biochemistry|
My research interests center on metabolomics and its application in biological and biochemical research. Specifically, I am interested in developing mass spectrometry (MS)-based metabolomics protocol and technology, and applying the techniques in profiling changes of metabolism in animals, plants and microbes in response to genetic and/or environmental disturbances.
Metabolomics is the systematic identification and quantification of the cellular metabolites (or small-molecules) using advanced technologies combined with multivariate statistical methods for data interpretation. These advanced technologies include high resolution mass spectrometry coupled to gas chromatograph (GC-MS) or ultrahigh performance liquid chromatograph (UPLC-MS), LC-MS-SPE (solid phase extraction)-NMR (nuclear magnetic resonance).
Qiu, F., Fine, D. D. Wherritt, D.J., Lei, Z. and Lloyd W. Sumner, L.W. (2016) PlantMAT: A Metabolomics Tool for Predicting the Metabolic Potential of a System and for Large-scale Metabolite Identifications. Anal. Chem. 88 (23), pp 11373–11383.
Zhang, W., Lei, Z., Huhman, D., Sumner, L.W. and Zhao, P. X. (2015) MET-XAlign: A Metabolite Cross-alignment Tool for LC/MS-based Comparative Metabolomics. Anal. Chem. 87 (18), 9114–9119.
Lei, Z., Jing, L., Qiu, F., Zhang, H., Huhman, D., Zhou, Q. and Sumner, L.W. (2015) Construction of a UHPLC-Tandem Mass Spectral Library of Plant Natural Products and Comparative Spectral Analyses. Anal. Chem. 87 (14), pp 7373–7381.
Jing, L., Lei, Z., Zhang, G., Pilon, A.C., Huhman, D., Tawfall-Forthman, A., Xie, R., Xi, W., Li, L., Zhou, Z. and Sumner, L. W. (2015) Metabolite profiles of Chinese native Citrus species and their taxonomic implications. Metabolomics. 11(4), 952-963.
Sumner L.W., Lei, Z., Nikolau, B.J., Saito, K., Roessner, U. and Trengove, R. (2014) Proposed quantit,ative and alphanumeric metabolite identification metrics. Metabolomics. 10:1047–1049.
Sumner, L.W., Lei, Z., Nikolau, B.J. and Saito, K. (2014) Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects. Nat Prod Rep. 32, 212-229.
Zhang, W., Chang, J., Lei, Z., Huhman, D., Sumner, L.W., Zhao, P. X. (2014) MET-COFEA: a liquid chromatography/mass spectrometry data processing platform for metabolite compound feature extraction and annotation. Anal. Chem. Jul 1; 86(13):6245-53.
Jing, L., Lei, Z., Li, L., Xie, R., Xi, W., Guan, Y., Sumner, L.W. and Zhou, Z. (2014) Antifungal activity of citrus essential oils. J. Agric. Food Chem. 62(14), 3011–3033.
Creek, D.J., Dunn, W.B., Fiehn, O. Griffin, J. L., Hall, R.D., Lei, Z., Mistrik, R., Neumann, S., Schymanski, E.L., Sumner, L.W., Trengove, R. and Wolfender J.-L. (2014) Metabolite identification: are you sure? And how do your peers gauge your confidence? Metabolomics 10(3), 350-353.