Susan L. Deutscher
Professor of Biochemistry
E-mail:deutschers@missouri.edu
Office: 234C Schweitzer Hall
Mail: Biochemistry
117 Schweitzer Hall
University of Missouri
Columbia, MO 65211
Phone: 573-882-2454
Fax: 573-882-5635
Lab: 573-882-1493
Educational background
| Degree | School | Location | Major |
| BS | Purdue University | West Lafayette, Ind. | Cell Biology |
| PhD | St. Louis University | St. Louis, Mo. | Biochemistry |
Notable honors and service
- Co-director, NIH/NEI Center for Single Photon-Emitting Cancer-Imaging Agents
- Veterans Administration Research Merit Award (1994-96; 1998-2020)
Research description
Our laboratory is interested in discerning the role of carbohydrate and protein-protein interactions in cancer. Work focuses on applying novel combinatorial phage display approaches and structural biochemistry to characterize these interactions. Combinatorial chemistry and phage display allows for the rapid selection from many millions of sequences to find peptide molecules that bind almost any given target such as cancer antigens. We have isolated peptides that are being utilized to specifically modulate cancer cell adhesion events. Once radiolabeled, the peptides will prove valuable as selective cancer imaging and therapeutic agents.
Selected publications
Newton-Northup JR, Deutscher SL. Cytotoxic Tumor-Targeting Peptides From In Vivo Phage Display. Combinatorial Chemistry and High Throughput Screening, 19:370-377 (2016).
Larimer BM, Deutscher SL. Development of a Peptide by Phage Display for SPECT Imaging of Resistance-Susceptible Breast Cancer. American Journal of Nuclear Medicine and Molecular Imaging, 4:435-447. doi:2160-8407/ajnmmi0000680 (2014).
Newton-Northup JR, Dickerson MT, Smith GP, and Deutscher SL. In Vivo Bacteriophage Peptide Display to Tailor Pharmacokinetics of Biological Nanoparticles. Molecular Imaging and Biology. doi:10.1007/s11307-014-0762-z (2014).
Tessier MB, Grant OC, Heimburg-Molinaro J, Smith D, Jadey S, Gulick AM, Glushka J, Deutscher SL, Rittenhouse-Olson K, Woods RJ. Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11. PLoS One. 2013;8(1):e54874. doi: 10.1371/journal.pone.0054874. Epub 2013 Jan 24.
Newton-Northup JR, Dickerson MT, Ma L, Besch-Williford CL, Deutscher SL. Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide. Clin Exp Metastasis. 2013 Feb;30(2):119-32. doi: 10.1007/s10585-012-9516-y. Epub 2012 Aug 1.
Kumar SR, Gallazzi FA, Quinn TP, Deutscher SL. (64)Cu-labeled peptide for PET of breast carcinomas expressing the Thomsen-Friedenreich carbohydrate antigen. J Nucl Med. 2011 Nov;52(11):1819-26. doi: 10.2967/jnumed.111.093716. Epub 2011 Oct 7.
Employment opportunities
Postdoctoral opportunities
Research areas: Combinatorial biology applied to cancer detection and therapy.
How to apply:
Electronic submission is encouraged, e-mail to deutschers@missouri.edu
Applicants should send CV and names of two references to:
Dr. Susan L. Deutscher
Biochemistry
117 Schweitzer Hall
University of Missouri
Columbia, MO 65211